Transcription profiling of rats from inbred alcohol-preferring and -non-preferring strains in five brain regions

ABSTRACT: The objective of this study was to test the hypothesis that innate differences in gene expression in the brain could; contribute to the differences in alcohol drinking or response to alcohol between adult male inbred alcohol-preferring (iP) and -non-preferring; (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU) and; hippocampus (HIP) of alcohol-naïve adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Significant differences between the two strains for each region were determined using Statistical Analysis of Microarrays (SAM). Using a false discovery rate threshold of 0.2, there were 46 genes with higher expression in iP rats and 61 genes with lower expression in; th

ORGANISM(S): Rattus norvegicus

SUBMITTER: Mark William Kimpel 

PROVIDER: E-GEOD-4494 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress