Mitochondrial two-component signaling systems in Candida albicans

ABSTRACT: Two-component signal transduction pathways are one of the primary means by which microorganisms respond to environmental signals. These signaling cascades originated in prokaryotes and were inherited by eukaryotes via endosymbiotic lateral gene transfer from ancestral cyanobacteria. We report here that the nuclear genome of pathogenic fungus Candida albicans contains elements of a two-component signaling pathway that seem to be targeted to the mitochondria. In C. albicans two-component response regulator protein Srr1(Stress Response Regulator) contains a mitochondrial targeting sequence at the N-terminus, and fluorescence microscopy reveals mitochondrial localization of GFP-tagged Srr1p. Moreover, phylogenetic analysis indicates that C. albicans Srr1p is more closely related to histidine k

ORGANISM(S): Candida albicans

SUBMITTER: Kathy Barker 

PROVIDER: E-GEOD-45438 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress