The Plasma Cell Signature in Autoimmune Disease (II)

ABSTRACT: Objective: Production of pathogenic autoantibodies by self-reactive plasma cells (PC) is a hallmark of autoimmune diseases. Investigating the prevalence of PC in autoimmune disease and their relationship with known pathogenic pathways may increase our understanding of the role of PC in disease progression and treatment response. Methods: We developed a sensitive gene expression based method to overcome the challenges of measuring PC using flow cytometry. Whole genome microarray analysis of sorted cellular fractions identified a panel of genes, IGHA, IGJ, IGKC, IGKV, and TNFRSF17, expressed predominantly in PC. The sensitivity of the PC signature score created from the combined expression levels of these genes was assessed through ex vivo experiments with sorted cells. This PC gene expr

ORGANISM(S): Homo sapiens

SUBMITTER: Christopher Morehouse 

PROVIDER: E-GEOD-45536 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress