Clonal evolution, genomic drivers, and effects of therapy in chronic lymphocytic leukemia

ABSTRACT: The identification of gene mutation and structural genomic aberrations that are critically involved in CLL pathogenesis is still evolving. One may postulate that genomic driver lesions with effects on CLL proliferation, apoptosis thresholds, or chemotherapy resistance should increase in frequency over time when measured sequentially in a large CLL cohort. We sequentially sampled a large, well-characterized CLL cohort at a mean of 4 years between samplings. The paired analysis included 156 patients, of whom 114 remained untreated and 42 received intercurrent therapies. Results: we identify a strong effect of intercurrent therapies on the frequency of acquisition of aCNAs in CLL. Importantly, the spectrum of acquired genomic changes was largely similar in patients that did or did not r

ORGANISM(S): Homo sapiens

SUBMITTER: Sami Malek 

PROVIDER: E-GEOD-45565 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress