Leukemia Cell Lines Induce Changes in Bone Marrow Stromal Cells

ABSTRACT: Bone marrow derived stromal cells (BMSCs) are a multipotent population that supports angiogenesis, wound healing, immunomodulation and plays an active role in the hematopoietic niche. On the other hand, they are also involved in the nurturing of bone marrow tumors and metastasis, showing a pro-tumorigenic behavior. BMSCs secrete a wide range of cytokines, growth factors and matrix proteins that are likely responsible for many of these effects. However, it is not clear whether this pro-tumorigenic behavior of BMSCs is induced by the tumor cells, neither in what extent the tumor cells affect the type and quantity of factors produced by BMSCs. To determine how tumor cells that arise from bone marrow affect the BMSCs, we selected three myeloid leukemia cell lines (TF-1, TF-1alpha and K562) and

ORGANISM(S): Homo sapiens

SUBMITTER: PING JIN 

PROVIDER: E-GEOD-45663 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress