Allele special primer extension microarray for test 12 SNPs contributed to NSCL/P in northeast China.

ABSTRACT: Nonsyndromic cleft lip with or without palate (NSCL/P) are common birth defects of complex etiology. Multiple interacting loci with possible additional environment factors influence the risk for NSCL/P. 12 single nucleotide polymorphisms (SNPs) in 7 candidate genes were tested using an allele-specific primer extension for both case-control and case-parents analyses in northeast China (236 unrelated patients, 185 mothers and 154 fathers, including 128 complete trios, 400 control individuals). TGFA and IRF6 genes showed a significant associations with NSCL/P. For IRF6, statistical evidence of association between rs2235371 (P=0.003), rs2013162 (P=0.000) and NSCL/P was found in case-control analyses. The Family Based Association Tests (FBAT) showed an over-transmission for C allele of rs223537

ORGANISM(S): Homo sapiens

SUBMITTER: lu yongping 

PROVIDER: E-GEOD-45770 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress