Gene expression analysis of human heart valves

ABSTRACT: Semilunar valve leaflets have a well-described trilaminar histoarchitecture with a sophisticated elastic fiber network. It was previously proposed that elastin-containing fibers play a subordinate role in early human cardiac valve development; however, this assumption was based on data obtained from mouse models and human second and third trimester tissues. Here, we systematically analyzed tissues from human fetal first (4-12 weeks) and second (13-18 weeks) trimester, adolescent (14-19 years) and adult (50-55 years) hearts to monitor the temporal and spatial distribution of elastic fibers, focusing on semilunar valves. Global gene expression analyses revealed that the transcription of genes essential for elastic fiber formation starts early within the first trimester. These data were confi

ORGANISM(S): Homo sapiens

SUBMITTER: Shannon Layland 

PROVIDER: E-GEOD-45821 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress