The conserved DNA-binding protein WhiA is involved in cell division in Bacillus subtilis

ABSTRACT: One of the first steps in bacterial cell division is the polymerization of the tubulin-like protein FtsZ at midcell. The dynamics of FtsZ polymerization is regulated by a set of proteins among which ZapA. A zapA mutation does not result in a clear phenotype in Bacillus subtilis. In this study we used a synthetic-lethal screen to find genes that become essential when ZapA is absent. Three transposon insertions were found in yvcL. Deletion of yvcL in a wild type background had only a mild effect on growth, but a yvcL zapA double mutant is very filamentous and sick. This filamentation is caused by a strong reduction in FtsZ polymerization, suggesting that YvcL is involved in an early stage of cell division. YvcL is 25 % identical and 50 % similar to the Streptomyces coelicolor transcription f

ORGANISM(S): Bacillus subtilis

SUBMITTER: Paul Wackers 

PROVIDER: E-GEOD-45824 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress