FGFR2 Signaling Underlies p63 Oncogenic Function in Squamous Cell Carcinoma

ABSTRACT: This study was designed to examine the requirement for the p63 transcription factor in Squamous Cell Carcinoma (SCC) tumor maintenance in an in vivo murine system. A tamoxifen-inducible Keratin 14-driven Cre recombinase transgene was used to conditionally excise p63 in advanced murine SCC tumors. These data show the context-dependent regulation of p63 target genes in cancer. Total RNA from murine Squamous Cell Carcinoma tumors was examined 1-3 days following genomic excision of TP63 in Keratin 14-expressing tumor cells.

ORGANISM(S): Mus musculus

SUBMITTER: Matthew Ramsey 

PROVIDER: E-GEOD-45929 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress