Inactive or moderately active human promoters are enriched for inter-individual epialleles [Methylation BeadChip]

ABSTRACT: We first demonstrate that non-genetically determined inter-individual differentially methylated regions (iiDMRs) can be temporally stable for at least two years. Then, we show that iiDMRS are associated with concomitant changes in chromatin state as measured by inter-individual differences in the levels of the histone variant H2A.Z. However, the correlation of promoter iiDMRs with gene expression is negligible and this correlation is not improved even by integrating H2A.Z information. We find that most promoter epialleles, whether genetically or non-genetically determined, are associated with low levels of transcriptional activity, depleted for house keeping genes, and either depleted for H3K4me3/enriched for H3K27me3, or lacking both these marks in human embryonic stem cells. These findin

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Down 

PROVIDER: E-GEOD-46168 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress