Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks

ABSTRACT: Eukaryotic chromatin is separated into functional domains differentiated by posttranslational histone modifications, histone variants, and DNA methylation. Methylation is associated with repression of transcriptional initiation in plants and animals, and is frequently found in transposable elements. Proper methylation patterns are critical for eukaryotic development, and aberrant methylation-induced silencing of tumor suppressor genes is a common feature of human cancer. In contrast to methylation, the histone variant H2A.Z is preferentially deposited by the Swr1 ATPase complex near 5' ends of genes where it promotes transcriptional competence. How DNA methylation and H2A.Z influence transcription remains largely unknown. Here we show that in the plant Arabidopsis thaliana, regions of

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Jorja Henikoff 

PROVIDER: E-GEOD-12212 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress