Transcription profiling of human LNCaP cells treated with DHT, RTI-6413-018 or vehicle to identify useful Selective Androgen Receptor Modulators (SARMs)

ABSTRACT: We have previously identified a family of novel androgen receptor (AR) ligands that, upon binding, enable AR to adopt structures distinct from that observed in the presence of canonical agonists. In this report, we describe the use of these compounds to establish a relationship between AR structure and biological activity with a view to defining a rational approach with which to identify useful Selective Androgen Receptor Modulators (SARMs). As one of the approaches, we used a DNA microarray analysis to demonstrate that differently conformed receptors facilitate distinct patterns of gene expression in LNCaP cells. Interestingly, we observed a complete overlap in the identity of genes expressed following treatment with mechanistically distinct AR ligands. However, it was differences in the

ORGANISM(S): Homo sapiens

DISEASE(S): prostate carcinoma

SUBMITTER: Dmitri Kazmin 

PROVIDER: E-GEOD-4636 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress