Transcription of Tnfaip3 is regulated by NF-kB and p38 via C/EBPβ in activated macrophages

ABSTRACT: Macrophages play a pivotal role in the immune system through recognition and elimination of microbial pathogens. Toll-like receptors (TLRs) on macrophages interact with microbial substances and initiate signal transduction through intracellular adapters. TLR4, which is important for the response to lipopolysaccharide (LPS), triggers downstream signaling mediators and eventually activates IkB kinase (IKK) complex and mitogen-activated protein kinases (MAPKs) such as p38. Previous reports revealed that, in addition to NF-kB, the induction of some LPS-inducible genes in macrophages required another transcription factor whose activity depends on p38. However, these transcription factors remained to be identified. Among these genes, NF-kB and C/EBPβ, a p38 downstream transcription factor, were

ORGANISM(S): Mus musculus

SUBMITTER: Mong-Hsun Tsai 

PROVIDER: E-GEOD-46361 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress