Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ren-he Xu
PROVIDER: E-GEOD-46485 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The Journal of biological chemistry 20131206 4
It has been recently reported that the regulatory circuitry formed by OCT4, miR-302, and NR2F2 controls both pluripotency and neural differentiation of human embryonic stem cells (hESCs). We show here that JMJD1C, a histone 3 lysine 9 (H3K9) demethylase expressed in hESCs, directly interacts with this circuitry. hESCs with stable knockdown of JMJD1C remain pluripotent while having reduced miR-302 expression, decreased BMP signaling, and enhanced TGFβ signaling. JMJD1C binds to the miR-302 promot ...[more]