Regulatory role of SrrAB two-component system in Staphylococcus epidermidis growth and biofilm formation

ABSTRACT: Biofilm formation is considered the most important factor involved in pathogenicity of Staphylococcus epidermidis.We investigated the role of two-component signal transduction system (TCS) srrAB, which was up-regulated under micro-aerobic condition, in the growth and biofilm formation of S. epidermidis.AsrrA-deficient mutant (M-bM-^HM-^FsrrA) derived from S. epidermidis1457 (SE1457), exhibited dramatic reduction in growth and biofilm formation underboth aerobic and micro-aerobic conditions, and more sensitive to several different types of antimicrobial agents, H2O2 and SDS. In New Zealand Rabbit model of S. epidermidis biofilm infection, M-bM-^HM-^FsrrA hardly formed biofilm compared to that of SE1457. Phenotypic alteration was restored to the wide-type levelwhen srrAB were complemented in

ORGANISM(S): Staphylococcus epidermidis

SUBMITTER: FRANCOIS Patrice 

PROVIDER: E-GEOD-47101 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress