Transcriptomic analyses of Staphylococcus epidermidis in mixed-species biofilms with Candida albicans

ABSTRACT: To explain enhanced biofilm formation and increased dissemination of S. epidermidis in mixed-species biofilms, microarrays were used to explore differential gene expression of S. epidermidis in mixed-species biofilms. One sample from single species biofilm (S1) and mixed-species biofilm (SC2) were excluded from analyses for outliers. We observed upregulation (2.7%) and down regulation (6%) of S. epidermidis genes in mixed-species biofilms. Autolysis repressors lrgA and lrgB were down regulated 36-fold and 27-fold respectively and was associated with increased eDNA possibly due to enhanced autolysis in mixed-species biofilms. These data suggest that bacterial autolysis and release of eDNA in the biofilm matrix may be responsible for enhancement and dissemination of mixed-species biofilms of

ORGANISM(S): Candida albicans

SUBMITTER: Mohan Pammi Venkatesh 

PROVIDER: E-GEOD-35438 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress