Lymph node CD4+ T cell and thioglycollate-elicited peritoneal macrophage expression data from naM-CM-/ve young and old SJL/J and SJL-ChrY^B10.S male mice

ABSTRACT: Understanding the DNA elements that constitute and control the regulatory genome is critical for the appropriate therapeutic management of complex diseases. Here, using chromosome Y (ChrY) consomic mouse strains on the C57BL/6J background, we show that susceptibility to two diverse animal models of autoimmune disease, including experimental allergic encephalomyelitis (EAE) and experimental myocarditis, correlates with the natural variation in copy number of Sly and Rbmy multicopy ChrY genes. In the B6 background, ChrY possesses gene regulatory properties that impact both genome-wide gene expression and the presence of alternative splice variants in pathogenic CD4+ T cells. Using a ChrY consomic strain on the SJL background, we discovered a preference for ChrY-mediated gene regulation in ma

ORGANISM(S): Mus musculus

SUBMITTER: Laure Case 

PROVIDER: E-GEOD-47437 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress