Lymph node CD4+ T cell expression data from naM-CM-/ve female offspring of C57BL/6J and C57BL/6J-ChrY^SJL

ABSTRACT: The prevalence of some autoimmune diseases (AID) is greater in females compared with males, notwithstanding that disease severity is often greater in males. The reason for this sexual dimorphism (SD) is unknown, but may reflect negative selection of Y chromosome (ChrY) bearing sperm during spermatogenesis or male fetuses early in the course of conception/pregnancy. Previously, we showed that the SD in experimental autoimmune encephalomyelitis (EAE) is associated with copy number variation (CNV) in ChrY multicopy genes. Here, we test the hypothesis that CNV in ChrY multicopy genes influences the paternal parent-of-origin effect on EAE susceptibility in female mice. We show that C57BL/6J consomic strains of mice possessing an identical ChrX and CNV in ChrY multicopy genes exhibit a female b

ORGANISM(S): Mus musculus

SUBMITTER: Laure Case 

PROVIDER: E-GEOD-65038 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress