Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Array CGH with DNA extracted from Candida albicans strains and its derivatives, which is monosomic for chromosome 5


ABSTRACT: Goal of this experiment was to confirm the proposed monosomy condition of chromsome 5 genes in the derivatives Pair-wise comparison of genomic content between parental strains and their derivatives.

ORGANISM(S): Candida albicans

SUBMITTER: Elena Rustchenko 

PROVIDER: E-GEOD-48093 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Chromosome 5 monosomy of Candida albicans controls susceptibility to various toxic agents, including major antifungals.

Yang Feng F   Kravets Anatoliy A   Bethlendy Gabor G   Welle Stephen S   Rustchenko Elena E  

Antimicrobial agents and chemotherapy 20130729 10


Candida albicans is a prevailing fungal pathogen with a diploid genome that can adapt to environmental stresses by losing or gaining an entire chromosome or a large portion of a chromosome. We have previously found that the loss of one copy of chromosome 5 (Ch5) allows for adaptation to the toxic sugar l-sorbose. l-Sorbose is similar to caspofungin and other antifungals from the echinocandins class, in that it represses synthesis of cell wall glucan in fungi. Here, we extended the study of the p  ...[more]

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