Ontology highlight
ABSTRACT:
ORGANISM(S): Candida albicans
SUBMITTER: Elena Rustchenko
PROVIDER: E-GEOD-48093 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Yang Feng F Kravets Anatoliy A Bethlendy Gabor G Welle Stephen S Rustchenko Elena E
Antimicrobial agents and chemotherapy 20130729 10
Candida albicans is a prevailing fungal pathogen with a diploid genome that can adapt to environmental stresses by losing or gaining an entire chromosome or a large portion of a chromosome. We have previously found that the loss of one copy of chromosome 5 (Ch5) allows for adaptation to the toxic sugar l-sorbose. l-Sorbose is similar to caspofungin and other antifungals from the echinocandins class, in that it represses synthesis of cell wall glucan in fungi. Here, we extended the study of the p ...[more]