Novel critical insights into the mechanism of cell-based therapy after myocardial infarction

ABSTRACT: Cell transplantation therapy is considered a novel and promising strategy in regenerative medicine. Recent studies point out that paracrine effects and inflammation induced by transplanted cells are key factors for the improvement of myocardial function. The present study aims at differentiating paracrine effects from inflammatory reactions after cell transplantation. Therefore, in vitro induced apoptotic bodies were transplanted after myocardial infarction in a rat model. Eight weeks after transplantation, the functional results showed no improvement in left ventricular function. Histological analysis revealed no significant differences in the amount of infiltrated cells and collagen content did not differ among the four groups, which sustains the functional data. Surprisingly, angiogenes

ORGANISM(S): Homo sapiens

SUBMITTER: Bernd Denecke 

PROVIDER: E-GEOD-48218 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress