Gene Expression Profiles in Engineered Cardiac Tissues Respond to Mechanical Loading and Inhibition of Tyrosine Kinase

ABSTRACT: Engineered cardiac tissues (ECTs) are platforms to investigate cardiomyocyte maturation and functional integration, to evaluate the feasibility of generating implantable tissues for cardiac repair and regeneration, and may be useful models for pharmacology and toxicology bioassays. These ECTs rapidly mature in vitro to acquire the features of functional cardiac muscle and respond to mechanical load with increased proliferation and maturation. ECTs can be generated from various immature cardiac cell sources and little is known regarding the broad changes in regulatory transcript expression that occur in these in vitro tissues during normal maturation and in response to mechanical or pharmacologic interventions. We tested the hypothesis that global ECT gene expression patterns are sensitiv

ORGANISM(S): Rattus norvegicus

SUBMITTER: Bradley Keller 

PROVIDER: E-GEOD-48342 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress