Mucosal transcriptomics implicates under expression of FAM5C in the pathogenesis of ulcerative colitis

ABSTRACT: Background and aims: Mucosal abnormalities are potentially important in the primary pathogenesis of ulcerative colitis (UC). We investigated the mucosal transcriptomic expression profiles of biopsies from patients with UC and healthy controls (HC), taken from macroscopically non-inflamed tissue from the terminal ileum and three colonic locations with the objective of identifying abnormal molecules that might be involved in disease development. Methods: Whole-genome transcriptional analysis was performed on intestinal biopsies taken from 24 UC, 26 HC and 14 patients with CrohnM-bM-^@M-^Ys disease. Differential gene expression analysis was performed at each tissue location separately and results were then meta-analysed using FisherM-bM-^@M-^Ys method. Significantly differentially express

ORGANISM(S): Homo sapiens

SUBMITTER: Professor Anthony Segal 

PROVIDER: E-GEOD-48634 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress