Transcription profiling of human peripheral blood monocytes treated with simvastatin reveals it has an anti-inflammatory effect on macrophages via upregulation of Kruppel-like factor-2

ABSTRACT: HMG-CoA reductase inhibitors, statins, have beneficial vascular effects beyond their cholesterol-lowering action. These pleiotropic effects include an anti-inflammatory effect on macrophages. Since macrophages play a central role in atherogenesis, we further characterized the effects on peripheral blood monocyte-macrophages (HPBM). Using Affymetrix gene chip analysis of simvastatin-treated HPBM, we found that simvastatin treatment lead to the downregulation of the expression of many proinflammatory genes including several chemokines (e.g. MCP-1, MIP-1 alpha and β, RANTES, several other CC and CXC chemokines, IL-2 receptor-β, and leukemia inhibitory factor), members of the tumor necrosis factor family (e.g. lymphotoxin beta and TRAIL), VCAM-1, ICAM-3, and tissue factor (TF). Simvastatin a

ORGANISM(S): Homo sapiens

SUBMITTER: Tiina Tuomisto 

PROVIDER: E-GEOD-4883 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress