Global signatures of protein binding on structural RNAs in Saccharomyces cerevisiae

ABSTRACT: Protein binding is essential to the transport, decay and regulation of almost all RNA molecules. However, the structural preference of protein binding on RNAs and their cellelar functions and dynamics upon changing environmental condictions are poorly understood. Here, we integrated various high-throughput data and introduced a computational framework to describe the global interactions between RNA binding proteins (RBPs) and structured RNAs in yeast at single-nucleotide resolution. We found that on average, in terms of percent total lengths, ~15% of mRNA untranslated regions (UTRs), ~37% of canonical ncRNAs and ~11% of long ncRNA (lncRNAs) are bound by proteins. The RBP binding sites, in general, tend to occur at single-stranded loops, with evolutionarily conserved signatures, and often f

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Mallory Freeberg 

PROVIDER: E-GEOD-48888 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress