Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

ABSTRACT: We surveyed the DNA methylation levels of 435,941 CpG sites in samples from 764 children at diagnosis of ALL and from 27 children at relapse. This survey uncovered four characteristic methylation signatures. First, compared with control blood cells, the methylomes of ALL cells shared 9,406 predominantly hypermethylated CpG sites, independent of cytogenetic background. Second, each cytogenetic subtype of ALL displayed a unique set of hyper- and hypomethylated CpG sites. The CpG sites that constituted these two signatures differed in their functional genomic enrichment to regions with marks of active or repressed chromatin. Third, we identified subtype-specific differential methylation in promoter and enhancer regions that were strongly correlated with gene expression. Fourth, a set of 6,612

ORGANISM(S): Homo sapiens

SUBMITTER: Jessica Nordlund 

PROVIDER: E-GEOD-49031 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress