Transcription profiling of mouse pooled embryonic humeri E14.5 from wild type and RUNX2-/- mutants detects novel skeletogenesis target genes
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jochen Hecht
PROVIDER: E-GEOD-4911 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Detection of novel skeletogenesis target genes by comprehensive analysis of a Runx2(-/-) mouse model.
Hecht J J Seitz V V Urban M M Wagner F F Robinson P N PN Stiege A A Dieterich C C Kornak U U Wilkening U U Brieske N N Zwingman C C Kidess A A Stricker S S Mundlos S S
Gene expression patterns : GEP 20060606 1-2
Runx2 is an essential factor for skeletogenesis and heterozygous loss causes cleidocranial dysplasia in humans and a corresponding phenotype in the mouse. Homozygous Runx2-deficient mice lack hypertrophic cartilage and bone. We compared the expression profiles of E14.5 wildtype and Runx2(-/-) murine embryonal humeri to identify new transcripts potentially involved in cartilage and bone development. Seventy-one differentially expressed genes were identified by two independent oligonucleotide-micr ...[more]
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