RECQL5 Controls Transcript Elongation and Suppresses Transcription-Associated Genome Instability
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Richard Mitter
PROVIDER: E-GEOD-49134 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress.
Saponaro Marco M Kantidakis Theodoros T Kantidakis Theodoros T Mitter Richard R Kelly Gavin P GP Heron Mark M Williams Hannah H Söding Johannes J Stewart Aengus A Svejstrup Jesper Q JQ
Cell 20140515 5
RECQL5 is the sole member of the RECQ family of helicases associated with RNA polymerase II (RNAPII). We now show that RECQL5 is a general elongation factor that is important for preserving genome stability during transcription. Depletion or overexpression of RECQL5 results in corresponding shifts in the genome-wide RNAPII density profile. Elongation is particularly affected, with RECQL5 depletion causing a striking increase in the average rate, concurrent with increased stalling, pausing, arres ...[more]
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