CSR-1 mediates RNA activation, RNAa, a self-RNA recognition pathway that promotes gene expression in the C. elegans germline

ABSTRACT: Epigenetic inheritance is the transmission of information independently of the nucleotide sequence of the genome. A fundamental question in biology is to what extent does epigenetics contribute to trans-generational inheritance. Here we investigate the role of Argonaute-small-RNA pathways in epigenetic inheritance in the nematode C. elegans. Argonautes present their guide RNAs for base-pairing with target sequences and, upon binding, can cleave the target RNA and/or recruit cofactors that mediate post-transcriptional or transcriptional silencing 1,2. Previous studies have shown that Argonaute small-RNA pathways reinforce and maintain epigenetic silencing in C. elegans 3-5. For example, the conserved PIWI-related Argonaute PRG-1 initiates a remarkably stable mode of epigenetic silencing,

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Craig Mello 

PROVIDER: E-GEOD-49532 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress