Methylation profiles of Chronic kidney disease

ABSTRACT: Epidemiological studies indicate that adverse intrauterine and postnatal environment has a long-lasting role in chronic kidney disease (CKD) development. Epigenetic information can represent a plausible carrier for mediating this "programming" effect. Here we demonstrate that genome-wide cytosine methylation patterns of healthy and CKD tubule samples obtained from patients show significant differences. We rarely observed differentially methylated regions (DMR) on promoters. Histone modification-based kidney specific genome-wide gene regulatory region annotation maps (promoters, enhancers, transcribed and repressed regions) were generated. DMRs mostly overlapped with putative enhancer regions and were enriched in consensus binding sequences for important renal transcription factor

ORGANISM(S): Homo sapiens

SUBMITTER: Yi-An Ko 

PROVIDER: E-GEOD-49557 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress