Genome-wide mapping of REST-bound sites in human CD4+ T cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Shira Rockowitz
PROVIDER: E-GEOD-49570 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Comparison of REST cistromes across human cell types reveals common and context-specific functions.
Rockowitz Shira S Lien Wen-Hui WH Pedrosa Erika E Wei Gang G Lin Mingyan M Zhao Keji K Lachman Herbert M HM Fuchs Elaine E Zheng Deyou D
PLoS computational biology 20140612 6
Recent studies have shown that the transcriptional functions of REST are much broader than repressing neuronal genes in non-neuronal systems. Whether REST occupies similar chromatin regions in different cell types and how it interacts with other transcriptional regulators to execute its functions in a context-dependent manner has not been adequately investigated. We have applied ChIP-seq analysis to identify the REST cistrome in human CD4+ T cells and compared it with published data from 15 othe ...[more]
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