Dissection of thousands of cell type-specific enhancers identifies dinucleotide repeat motifs as general enhancer features

ABSTRACT: Gene expression is determined by genomic elements called enhancers, which contain short motifs bound by different transcription factors (TFs). However, how enhancer sequences and TF motifs relate to enhancer activity is unknown and general sequence requirements for enhancers or comprehensive sets of important enhancer sequence elements have remained elusive. Here, we computationally dissect thousands of functional enhancer sequences from three different Drosophila cell lines. We find that the enhancers display distinct cis-regulatory sequence signatures, which are predictive of the enhancersM-bM-^@M-^Y cell type-specific or broad activities. These signatures contain transcription factor motifs and a novel class of enhancer sequence elements, dinucleotide repeat motifs (DRMs). DRMs are hig

ORGANISM(S): Drosophila melanogaster

SUBMITTER: J. Omar Yanez-Cuna 

PROVIDER: E-GEOD-49809 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress