Endothelin2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis

ABSTRACT: Endothelin signaling is required for neural crest migration and homeostatic regulation of blood pressure. Here we report that constitutive over-expression of Endothelin-2 (Edn2) in the mouse retina perturbs vascular development by inhibiting endothelial cell (EC) migration across the retinal surface and subsequent EC invasion into the retina. Developing endothelial cells exist in one of two states: tip cells at the growing front, and stalk cells in the vascular plexus behind the front. This division of endothelial cell states is one of the central organizing principle of angiogenesis. In the developing retina, Edn2 over-expression leads to over-production of endothelial tip cells by both morphologic and molecular criteria. Spatially localized over-expression of Edn2 produces a correspo

ORGANISM(S): Mus musculus

SUBMITTER: Amir Rattner 

PROVIDER: E-GEOD-50059 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress