Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide maps of Runx3 bound regions in IL-2-activated splenic NK cells

ABSTRACT: ChIP-seq was conducted using splenic WT NK cells cultured for 7 days with IL-2 using anti-Runx3 antibodies (Ab), anti-H3K4me1 Ab and non-immune serum (NIS) as control. Two biological Runx3, one H3K4me1 and two NIS IP repeats from splenic NK cells isolated from individual mice by negative selection using NK cell isolation kit (R&D) cultured with IL-2.

ORGANISM(S): Mus musculus

SUBMITTER: Joseph Lotem 

PROVIDER: E-GEOD-50129 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Runx3-mediated transcriptional program in cytotoxic lymphocytes.

Lotem Joseph J   Levanon Ditsa D   Negreanu Varda V   Leshkowitz Dena D   Friedlander Gilgi G   Groner Yoram Y  

PloS one 20131113 11

The transcription factor Runx3 is highly expressed in CD8(+) T and NK cytotoxic lymphocytes and is required for their effective activation and proliferation but molecular insights into the transcription program regulated by Runx3 in these cells are still missing. Using Runx3-ChIP-seq and transcriptome analysis of wild type vs. Runx3(-/-) primary cells we have now identified Runx3-regulated genes in the two cell types at both resting and IL-2-activated states. Runx3-bound genomic regions in both  ...[more]

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