Contextual fear conditioning in the mouse hippocampus

ABSTRACT: A fundamental question in neuroscience is how memories are stored and retrieved in the brain. Many neurological, psychiatric and neurodevelopmental disorders are associated with cognitive deficits. Therefore characterizing the biological basis of these processes is critical for understanding normal and abnormal brain function. It is known that long-term memory formation requires transcription and translation as well as epigenetic processes that control gene expression. In this study we examined genome-wide gene expression changes during memory consolidation and after memory retrieval. We observe the largest changes in gene expression 30 minutes after memory acquisition and retrieval, and several novel genes were found to be affected by both. Interestingly, acquisition and retrieval of mem

ORGANISM(S): Mus musculus

SUBMITTER: Lucia Peixoto 

PROVIDER: E-GEOD-50423 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress