Genome-scale DNA methylation maps of Zebrafish Muller glia during retina regeneration

ABSTRACT: Upon retinal injury, zebrafish Müller glia (MG) transition from a quiescent supportive cell to a progenitor cell (MGPC). This event is accompanied by the induction of key transcription and pluripotency factors. Because somatic cell reprogramming during iPSC generation is accompanied by changes in DNA methylation, especially in pluripotency factor gene promoters, we were interested in determining if DNA methylation changes also underlie MG reprogramming following retinal injury. Consistent with this idea, we found that genes encoding components of the DNA methylation/demethylation machinery were induced in MGPCs and that manipulating MGPC DNA methylation with 5-aza-2’-deoxycytidine altered their properties. A comprehensive analysis of the DNA methylation landscape as MG reprogram to MGPCs r

ORGANISM(S): Danio rerio

SUBMITTER: Ana Grant 

PROVIDER: E-GEOD-50717 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress