Candida albicans response to spaceflight (NASA STS-115)

ABSTRACT: This study presents the first global transcriptional profiling and phenotypic characterization of the major human opportunistic fungal pathogen, Candida albicans, grown in spaceflight conditions. Microarray analysis revealed that C. albicans subjected to short-term spaceflight culture differentially regulated 454 genes compared to synchronous ground controls, which represented 8.4% of the analyzed ORFs. Spaceflight-cultured C. albicans induced genes involved in cell aggregation (similar to flocculation), which was validated by microscopic and flow cytometry analysis. We also observed enhanced random budding of spaceflight-cultured cells as opposed to more normal bipolar budding patterns for ground samples, in accordance with the gene expression data. Furthermore, genes involved in antifung

ORGANISM(S): Candida albicans

SUBMITTER: Sheila Nielsen 

PROVIDER: E-GEOD-50881 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress