Genes induced by IFN-beta, IFN-gamma or unphosphoraylted STAT1 in human fibroblasts

ABSTRACT: A single high dose of IFN? activates powerful cellular responses in which many antiviral, pro-apoptotic, and anti-proliferative proteins are highly expressed. Since some of these proteins are deleterious, cells down-regulate this initial response rapidly. However, the expression of many antiviral proteins that do no harm is sustained, prolonging a substantial part of the initial antiviral response for days and also providing resistance to DNA damage. While the transcription factor ISGF3 (IRF9 and tyrosine-phosphorylated STATs 1 and 2) drives the first rapid response phase, the related factor un-phosphorylated ISGF3 (U-ISGF3), formed by IFN?-induced high levels of IRF9 and STATs 1 and 2 without tyrosine phosphorylation, drives the second prolonged response. The U-ISGF3-induced antiviral g

ORGANISM(S): Homo sapiens

SUBMITTER: HyeonJoo Cheon 

PROVIDER: E-GEOD-50954 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress