Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Pierre de la Grange
PROVIDER: E-GEOD-51203 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
EMBO reports 20140317 5
Alternative RNA processing of LMNA pre-mRNA produces three main protein isoforms, that is, lamin A, progerin, and lamin C. De novo mutations that favor the expression of progerin over lamin A lead to Hutchinson-Gilford progeria syndrome (HGPS), providing support for the involvement of LMNA processing in pathological aging. Lamin C expression is mutually exclusive with the splicing of lamin A and progerin isoforms and occurs by alternative polyadenylation. Here, we investigate the function of lam ...[more]