Expression and Metabolic Profiles in a Panel of Five Neural Tube Defect Mouse Models

ABSTRACT: Neural tube defects (NTDs) are serious birth defects with an estimated worldwide incidence of 1 per 1,000 live births. The multifactorial nature of NTDs in humans has made it difficult to elucidate pathogenesis mechanisms. However, a strong relationship has been established between folate-homocysteine metabolism and NTD risk. Prevention of a substantial proportion of fetal NTDs can be achieved through maternal folic acid (FA) supplementation. However the mechanism by which FA exerts its beneficial effect remains unclear. METHODS: To improve our understanding of the underlying mechanisms of NTD pathogenesis and the ways in which folate exerts its beneficial effect, we analyzed mRNA profiles as well as folate and vitamin B12 levels in five NTD mouse mutants whose response to dietary FA was p

ORGANISM(S): Mus musculus

SUBMITTER: Joseph Nadeau 

PROVIDER: E-GEOD-51285 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress