All trans-retinoic acid (ATRA) re-differentiate early transformed breast epithelial cells to normal.

ABSTRACT: Retinoids have been used as potential chemotherapeutic or chemo-preventive agents because of their differentiation, anti-proliferative, pro-apoptotic, and anti-oxidant effects. We investigated the effect of all trans- retinoic acid (ATRA) at different stages of the neoplastic transformation using an in vitro model of breast cancer progression. This model was previously developed by treating the human normal-like breast epithelial MCF-10F cells with high dose of estradiol and consist of five cell lines which shown a progressive neoplastic transformation: MCF-10F (normal stage), trMCF (premalignant stage), bsMCF (invasive stage) and caMCF (tumorigenic stage). In 3D-cultures, MCF-10F cells form tubules resembling the normal mammary gland although after treatment with high doses of estradiol,

ORGANISM(S): Homo sapiens

SUBMITTER: Sandra Fernandez 

PROVIDER: E-GEOD-51549 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress