Affect of Socs2 loss-of-function on liver regeneration

ABSTRACT: SOCS2 Ensures Metabolic Function and Mass Restoration During Liver Regeneration - SOCS2 plays distinct and contrasting roles during liver regeneration. Early after injury, SOCS2 expression increases and limits the rate of regeneration, preserving metabolic activity. Surprisingly, at later times, the role of SOCS2 reverses to promote liver regeneration by stimulating GH release from the pituitary via effects on serum levels of insulin-like growth factor 1. Loss of SOCS2 promotes GH signaling by increasing growth hormone receptor levels and driving phosphorylation of proteins in the GH pathway, establishing a state of hyper-responsiveness to GH. These findings suggest a single protein can play contrasting roles at different times after liver injury and modulation of GH signaling achieves

ORGANISM(S): Mus musculus

SUBMITTER: Michael Todd Valerius 

PROVIDER: E-GEOD-51801 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress