Transcription profiling of mouse Nrf2 knockout caused by ROS-mediated insulin/IGF-1 resistance

ABSTRACT: The liver is frequently challenged by surgery-induced metabolic overload, viruses, or toxins, which induce the formation of reactive oxygen species. To determine the effect of oxidative stress on liver regeneration and to identify the underlying signalling pathways, we studied liver repair in mice lacking the Nrf2 transcription factor. In these animals, expression of several cytoprotective enzymes was reduced in hepatocytes, resulting in oxidative stress. As a consequence, tissue damage was aggravated, and liver regeneration after partial hepatectomy was delayed. Using in vitro and in vivo studies we identified oxidative stress-induced insulin/insulin-like growth factor resistance as the underlying mechanism. This deficiency impaired the activation of p38 mitogen-activated kinase, Akt kina

ORGANISM(S): Mus musculus

SUBMITTER: Stefan Zoller 

PROVIDER: E-GEOD-8969 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress