Lung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features

ABSTRACT: Accumulation of genetic and epigenetic changes alters regulation of a web of interconnected genes including miRNAs, which confer hallmark capabilities and characteristic cancer features. In this study, the miRNA and mRNA expression profiles of 126 non-small cell lung cancer specimens were analyzed, with special attention given to the diversity of lung adenocarcinomas. Of those, 76 adenocarcinomas were classified into two major subtypes, developing lung-like and adult lung-like, based on their distinctive miRNA expression profiles resembling those of either developing or adult lungs, respectively. A systems biology-based approach using a Bayesian network and nonparametric regression was employed to estimate the gene regulatory circuitry functioning in patient tumors in order to identify sub

ORGANISM(S): Homo sapiens

SUBMITTER: Takashi Takahashi 

PROVIDER: E-GEOD-51853 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress