Dietary cholesterol supplementation to a plant-based diet for Atlantic salmon

ABSTRACT: The study evaluated effects of dietary cholesterol (1.5%) in Atlantic salmon fed a plant based diet for 77 days. Cholesterol supplementation did not affect growth or organ weights of Atlantic salmon, but promoted induction of cholesterol and plant sterol efflux in the intestine, whereas sterol uptake was suppressed. Microarray analyses in the liver indicated decreased cholesterol biosynthesis and enhanced conversion to bile acids. The marked effect of cholesterol on bile acid synthesis suggests that dietary cholesterol can be used to stimulate bile acid synthesis in fish. The study clearly demonstrated how Atlantic salmon adjusted metabolic functions in response to the dietary load of cholesterol, and has expanded our understanding of sterol metabolism and turnover that adds to the knowled

ORGANISM(S): Salmo salar

SUBMITTER: Aleksei Krasnov 

PROVIDER: E-GEOD-51887 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress