H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells [MSCs]

ABSTRACT: In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in repressive histone posttranslational modifications. However, the chromatin marks associated with changes in DNA methylation in adult stem cells during lifetime are still largely unknown. Here, DNA methylation profiling of mesenchymal stem cells obtained from individuals aged 2 to 92 identified 18735 hypermethylated and 45407 hypomethylated CpG sites associated with aging. As in differentiated cells, hypermethylated sequences were enriched in chromatin repressive marks. Most importantly, hypomethylated CpG sites were strongly enriched in the active chromatin mark H3K4me1 in stem and differentiated cells, suggesting this is a cell type-independent chromatin signature of DNA hypomethylation during ag

ORGANISM(S): Homo sapiens

SUBMITTER: Agustin Fernandez 

PROVIDER: E-GEOD-52112 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress