A Global Approach to Dissect Palmitate-induced Impairment of Hepatic Glucose Production

ABSTRACT: Obesity-induced insulin resistance of the liver is characterised by increased gluconeogenesis, which contributes to elevated blood glucose levels in individuals with type 2 diabetes. Research into how fatty acids induce insulin resistance has commonly focused on the induction of insulin resistance. We hypothesise that by shifting focus to the reversal of an insulin resistant phenotype, novel insights can be made into the mechanisms by which insulin resistance can be overcome. Using global gene and lipid expression profiling, we aimed to identify biological pathways altered in parallel with restoration of palmitate-induced deregulation of glucose production using metformin and sodium salicylate. FAO hepatoma cells were treated with palmitate (0.075mM, 48h) with or without metformin (0.25mM

ORGANISM(S): Rattus norvegicus

SUBMITTER: Bradley Hayward 

PROVIDER: E-GEOD-52204 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress