Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Hepatocyte
DISEASE(S): Disease Free
SUBMITTER: Raid Nisr
LAB HEAD: Graham Rena
PROVIDER: PXD053975 | Pride | 2025-05-26
REPOSITORIES: pride
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Nisr Raid B RB Atrih Abdelmadjid A Lara Erika J Gutierrez EJG Lamont Douglas D Luda Katarzyna M KM McCrimmon Rory J RJ Sakamoto Kei K Rena Graham G McNeilly Alison D AD
Acta physiologica (Oxford, England) 20250601 6
<h4>Aims</h4>The benefit of salicylate in the treatment of diabetes has been recognized for over a century; however, challenging side effects have prevented widespread use. A better understanding of the relevant enzyme targets mediating its anti-hyperglycaemic effect may lead to the development of novel therapies for diabetes. Here, we investigated the contribution of 5'-adenosine monophosphate (AMP)-dependent inhibition of fructose-1,6-bisphosphatase 1 (FBP1) to the anti-hyperglycaemic action o ...[more]