A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

ABSTRACT: Our data throw light upon the effect of WRN deficiency on gene expression and epigenomic modification, which indicates aging-associated changes from both genomic and epigenomic level. It was compared between WRN+/+ and WRN-/- in hESCs and hMSCs that the gene expression landscapes and epigenetic modifications(H3K4me3, H3K27me3, H3K9me3 and 5-methylcytosine).

ORGANISM(S): Homo sapiens

SUBMITTER: Jingyi Li 

PROVIDER: E-GEOD-52285 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress