The effects of chronic cadmium exposure on gene expression in MCF7 breast cancer cells

ABSTRACT: Cadmium is a metalloestrogen known to activate the estrogen receptor and promote breast cancer cell growth. Previous studies have implicated cadmium in the development of more malignant tumors; however the molecular mechanisms behind this cadmium-induced malignancy remain elusive. Using clonal cell lines derived by exposing breast cancer cells to cadmium for over 6 month (MCF7-Cd4, -Cd6, -Cd7, -Cd8 and -Cd12), this study aims to identify gene expression signatures associated with chronic cadmium exposure. Our results demonstrate that prolonged exposure does not merely result in the deregulation of genes but actually leads to a distinctive expression profile. The genes deregulated in cadmium-exposed cells are involved in multiple biological processes (i.e cell growth, apoptosis, etc.) and m

ORGANISM(S): Homo sapiens

SUBMITTER: Zelmina Lubovac Pilav 

PROVIDER: E-GEOD-52404 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress