RNA-Seq based characterization of long non-coding RNA involved in respiratory viruses pathogenesis

ABSTRACT: We aimed at systematically inferring the regulatory functions of host lncRNAs in response to influenza A virus (IAV) and severe acute respiratory syndrome coronavirus (SARS-CoV) in the mouse model, using a ‘guilt-by-association’ approach which relies on finding which lncRNAs have similar expression profiles to protein-coding genes of known function. To build a large panel of diverse host responses to viral infection, we took advantage of the genetic diversity present in the 8 founder strains of the Collaborative Cross (CC) mouse resource. Extensive pulmonary host-response profiling was performed on mock and viral-infected lungs at 2 and 4 days post-infection using total RNA-Seq. Overall lncRNAs accounted for about 40% of total genes differentially expressed upon infections (5,329 DE lncRNA

ORGANISM(S): Mus musculus

SUBMITTER: Michael Katze 

PROVIDER: E-GEOD-52405 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress